his work presents sensitivity analysis of a model describing JAK/STAT and MAPK signaling to quantify the contribution of individual parameters to signal transduction in hepatocytes stimulated by interleukin-6 (IL-6). Results from the analysis are used as a guideline for which parts of the model benefit from further model refinement. Based upon this analysis an updated version of the model is derived and validated in experiments involving a green fluorescent protein (GFP) reporter system. The model predictions are in excellent agreement with the experimental results.
Reference
Z. Huang, Y. Chu, F. Senocak, A. Jayaraman, and J. Hahn. "Model Update of Signal Transduction Pathways in Hepatocytes based upon Sensitivity Analysis "
Proceedings Foundations of Systems Biology in Engineering 2007, Stuttgart, Germany, pp. 45-50 (2007)